Preparation and Dissolution Rate of Gliquidone Solid Dispersion
- VernacularTitle:格列喹酮固体分散体的制备及溶出度测定
- Author:
Zhenhua PAN
;
Bai XIANG
;
Yu FANG
;
Jiening DUN
- Publication Type:Journal Article
- Keywords:
Gliquidone;
Solid dispersion;
Dissolution rate;
PEG;
PVP
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare gliquidone solid dispersion and to investigate its dissolution rate. METHODS: The gliquidone solid dispersion was prepared by dissolvent- fusion method and dissolvent method with PEG- 6000( PEG) and PVP K30( PVP) as carriers. RESULTS: The results of in vitro dissolubility test showed that the higher the carrier ratio, the faster the drug dissolution. The in vitro dissolubility of solid dispersions was faster with PVP than with PEG as carrier. The dissolution rate of the gliquidone- PVP ( 1∶ 7) solid dispersion reached as high as above 70% in 10 minutes, which was superior to that of its bulk drug. CONCLUSION: The gliquidone solid dispersion has been prepared successfully.
