Study on Effects of Saikosaponin-d on TPA,PAI,MDA and NO in Rats with Liver Fibrosis
- VernacularTitle:柴胡皂苷d对肝纤维化大鼠TPA、PAI、MDA及NO影响的研究
- Author:
Fang WAN
;
Jingzhen GUO
;
Xin LI
;
Ping LI
;
Yuwu CHEN
;
Keming LI
;
Chen WANG
;
Yun ZHANG
;
Jing LI
;
Yan LIU
- Publication Type:Journal Article
- Keywords:
Saikosaponin-d(SSd);
Liver fibrosis;
Fibrinolytic activity;
Lipid peroxidation;
Nitric oxide(NO)
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of saikosaponin-d(SSd) on tissue plasminogen activator(TPA),plasminogen activator inhibitor(PAI),malonaldehyde(MDA) and NO in rats with liver fibrosis induced by dimethylnitrosamine(DMN).METHODS:Eighteen SD healthy rats were randomized to control group(NS ip qd for 4 weeks),model group(10mg? kg-1 DMN ip 3 times per week for 4 weeks) and SSd-treated group(10mg? kg-1 DMN ip 3 times per week + SSd 1.8 mg? kg-1 ip for 28 consecutive days).All rats were killed 1h after the last time of administration,blood samples were taken from abdominal aorta and liver samples were taken for the observation of pathology and detection of indices of TPA,PAI,MDA and NO etc.RESULTS:SSd could lessen the degree of liver fibrosis and improve the fibrinolytic activities of TPA and PAI,meanwhile,it showed clearance effect on MDA and marked protective effect on hepatic cells.There were significant differences between SSd-treated group and the model group.CONCLUSION:SSd exhibited protective function on experimental hepatic fibrosis in rats,which may be attributed to the improving of fibrinolytic activity,eliminating of lipid peroxidation and enhancing of NO level.
