Blood Concentration Monitoring of Valproic Acid: Clinical Evaluation
- VernacularTitle:丙戊酸血药浓度监测的临床评价
- Author:
Yan JIANG
;
Aier QIAN
;
Sulan ZOU
;
Chunyan QIAN
;
Li LI
- Publication Type:Journal Article
- Keywords:
Valproic acid;
Fluorescence polarization immunoassay;
Blood concentration
- From:
China Pharmacy
2005;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To analyze the therapeutic drug monitoring results of valproic acid( anti- epileptic drug) . METH-ODS: The concentrations of valproic acid in 226 cases in our hospital were determined by fluorescence polarization immunoassay. RESULTS: The results showed that 47. 79% were within the normal referenced concentration range, with average concentration at( 66. 19? 12. 13) ? g? mL- 1, 46. 90% were below the lower limit and 5. 31% were above the upper limit. CONCLUS-ION: The monitoring results are far from satisfactory. It is advisable to adopt individualized administration so as to achieve the goal of treatment.
