Potassium channel gene expression in myocardial sleeves of pulmonary vein and effects of amiodarone on rabbits with rapid atrial pacing
- VernacularTitle:快速心房起搏兔肺静脉心肌袖细胞膜钾通道基因表达及胺碘酮的影响
- Author:
Jiangrong WANG
;
Yinglong HOU
;
Liaosheng ZHOU
;
Mei GAO
;
Changwen SHI
;
Qing WANG
;
Yingying SUN
;
Wei LIU
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
Rapid atrial pacing;
Potassium channels;
Amiodarone;
Gene expression
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the potassium channel gene expression of myocardial sleeves of pulmonary vein and effects of amiodarone on rabbits with rapid atrial pacing.METHODS: Rabbits were divided into three groups(n=10),(1) the control group with sham operation and placebo;(2) the right atrial pacing(RAP) group at 600 beats/min with the placebo;(3) the amiodarone group treated for seven days with oral amiodarone at 100 mg ? kg-1 ? d-1.Based on RAP simultaneously,the messenger ribonucleic acid(mRNA) of specimen was measured by reverse transcription-polymerase chain reaction.RESULTS: Compared with the control group,Kv4.3(transient outward K+ current,Ito1) mRNA expression in RAP group was reduced by 51%(P
