Effect of pentoxifylline on caspases expression in islet beta-cells of NOD mice
- VernacularTitle:己酮可可碱对NOD小鼠胰岛?细胞caspases表达的影响
- Author:
Liping GU
;
Yijie WU
;
Yufei WANG
;
Nianwei SHI
;
Weiping DONG
- Publication Type:Journal Article
- Keywords:
Pentoxifylline;
Diabetes mellitus,insulin-dependent;
Apoptosis;
Caspases
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the intervention effect of pentoxifylline(PTX) on type 1 diabetes mellitus in non-obese diabetic(NOD)mice and explore its possible mechanism.METHODS: Eight-week-old NOD mice were treated with PTX to investigate the incidence of cyclophosphamide accelerating diabetes.The apoptosis of beta-cells was detected by TUNEL,the expressions of caspase-3 in islet of the NOD mice was checked by immunohistochemistry and the expressions of caspase-8 was determined by RT-PCR.RESULTS: The incidence of diabetes in PTX group was 40.63%,which was obviously lower than 69.70% in the control group(P
