Anti-angiogenesis effects of IFN-? on cultured HUVECs and human HCC bearing nude mouse
- VernacularTitle:IFN-?抑制HUVECs以及荷人肝癌裸小鼠血管生成的实验研究
- Author:
Di TANG
;
Lijian LIANG
;
Baogang PENG
;
Fan ZHOU
;
Shaoqiang LI
;
Xiaoyu YIN
- Publication Type:Journal Article
- Keywords:
Interferon-alpha;
Liver neoplasms;
Anti-angiogenesis
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the anti-angiogenesis effect of interferon-?(IFN-?) on cultured human umbilical vein endothelial cells(HUVECs) and human hepatocellular carcinoma(HCC) bearing nude mouse.METHODS: Anti-proliferation test,MTT test,tube-formation test,migration test on cultured HUVECs were employed and the tumor volume and microvascular desity(MVD) of IFN-? treated human hepatoma cell line(HuH7) were meassured.RESULTS: IFN-? displayed apparent inhibitory effects on cultured HUVECs in anti-proliferation test,MTT test,tube-formation test,migration test,and the tumor diameter and MVD in IFN-? treated HuH7 inoculated nude mouse group were significantly less than those in PBS treated HuH7 inoculated nude mouse group.CONCLUSION: IFN-? inhibits tumor growth through anti-angiogenesis.
