Expression of FOXP3 in human lung cancer tissue and its biological role
- VernacularTitle:核转录因子FOXP3在肺癌组织中的表达及意义
- Author:
Xiaoju ZHANG
;
Jinnong ZHANG
;
Yang JIN
;
Jianchu ZHANG
;
Xiaonan TAO
;
Ming BAI
- Publication Type:Journal Article
- Keywords:
CD4+CD25+ regulatory T cells;
Lung neoplasms;
Transcription factor FOXP3
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To localize the expression of forkhead/winged helix transcription factor(FOXP3) gene in different types of pathological lung tissues and explore its biological role in pathogenesis of human lung cancer.METHODS: By using RT-PCR and Western blotting,the expressions of FOXP3 mRNA and related protein in 153 samples including lung cancer(n=63),lung benign lesion(n=45) and normal lung tissues(n=45) were analyzed.RESULTS: The positive expressions of FOXP3 mRNA and its protein were observed in lung cancer and in benign lesion lung tissue samples with significant difference(P0.05).CONCLUSION: FOXP3 is a biomarker of CD4+CD25+ regulatory T cell.They are expressed both in lung cancer and benign lesion lung tissues,but not in normal lung tissue.The expression of FOXP3 is more intensive in cancer tissues than that in benign lesions.
