Experimental study of radiofrequency ablation combined with arsenious acid therapy on liver VX2 tumors in rabbits
- VernacularTitle:射频消融联合亚砷酸治疗兔肝VX2肿瘤的实验研究
- Author:
Menghui ZHANG
;
Qiaoling WANG
;
Xianbing KONG
;
Ruiqing SONG
;
Zhaohong GAN
;
Wei FAN
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
Liver Neoplasms/ther;
Radiofrequency Ablation;
Arsenious Acid;
Vascular Endothelial Growth Factor;
Disease Models,Animal
- From:
Chinese Journal of General Surgery
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of combining radiofrequency ablation(RFA) with arsenious acid(AA) locally to treat liver VX2 tumor in rabbits,and to explore its mechanism.Methods Twenty-eight New Zealand White rabbits with implanted liver VX2 tumors were randomly divided into four groups: control group(n= 7),AA group(n=7),RFA group(n=7),and combination(RFA+AA) group(n=7).ALT was measured before treatment and on the day 0,day 3,day 7 and day 14 after treatment,meanwhile ultrasonic(US) examination was performed.All rabbits were killed 14 days after treatment.Vascular endothelial growth factor(VEGF) was examined by immunohistochemistry,and the relationship of VEGF and gross tumor volume was analyzed.Results Combination(RAF+AA) therapy caused little damage to hepatic function but had better inhibited tumor growth.The level of VEGF in AA,RFA and RAF+AA group was lower than that of the control group(P
