Determination of Dolasetron Mesylate by HPLC
- VernacularTitle:HPLC法测定甲磺酸多拉司琼的含量
- Author:
Xiuli YANG
;
Dongkai WANG
;
Min YANG
;
Yang SONG
;
Lijun WANG
- Publication Type:Journal Article
- Keywords:
HPLC;
Dolasetron mesylate;
Content determination
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a HPLC method for the determination of dolastron mesylate.METHODS:The sample was separated on Diamonsil C18 column.The mobile phase consisted of acetonitrile-water-1mol? L-1 ammonium formate(450∶ 440∶ 110)(pH=8.0 adjusted with trithylamine)with a flow rate of 1.0mL? min-1.The UV detection wavelength was set at 285nm and the sample size was 20? L.RESULTS:The linear range of dolasetron mesylate was 24～ 56? g? min-1(r=0.999 6),with average recovery at 99.7%(RSD=0.74%).CONCLUSION:The established is simple,sensitive and reproducible,and suitable for the quality control of dolasetron mesylate.
