p38 MAPK signaling pathway is involved in the regulation of receptor-mediated endocytosis
- VernacularTitle:p38 MAPK信号通路参与受体介导的细胞内吞的调控
- Author:
Xiaowei GONG
;
Jie WEI
;
Yusheng LI
;
Weiwei CHENG
;
Peng DENG
;
Yong JIANG
- Publication Type:Journal Article
- Keywords:
p38 MAPK;
Receptor-mediated endocytosis;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the role of p38 MAPK signaling pathway in the receptor-mediated endocytosis.METHODS:The effects of p38 MAPK on the receptor-mediated endocytosis were observed by using Alexa 594-conjugated Transferrin,in the presence of p38 specific inhibitor SB203580 or ERK pathway specific inhibitor PD98059,or using p38 knockout techniques.RESULTS:In the process of receptor-mediated endocytosis,p38 was activated by phosphorylation.Furthermore,the receptor-mediated endocytosis was inhibited by pretreatment with SB203580 or p38 knockout,while pretreatment with PD98059 had no effect on this process.CONCLUSION:p38 MAPK signaling pathway plays a role in the regulation of receptor-mediated endocytosis.
