Effects of three Chinese formulas on BDNF,TrkB in rat contex and hippocampus with chronic immobilization stress
- VernacularTitle:三种中药复方对慢性束缚应激大鼠皮层和海马BDNF、TrkB的影响
- Author:
Jiaxu CHEN
;
Wei LI
;
Xin ZHAO
;
Hongyan XU
;
Zhufeng WANG
;
Guangxin YUE
;
Jianxin YANG
- Publication Type:Journal Article
- Keywords:
Stress;
Brain-derived neurotrophic factor;
Protein-tyrosine kinase;
Drugs,Chinese herbal
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the changes of brain-derived neruotrophic factor(BDNF),tyrosine kinase B(TrkB) in rat cortex and hippocampus with chronic immobilization stress and the influence of three Chinese formulas(Xiaoyaosan,Sijunzitang,Jinkuishenqiwan) on them.METHODS:Chronic immobilization stress method(180 min daily,repeated 7 days or 21 days) was taken,and the changes of BDNF,TrkB in rat forehead cortex and hippocampus CA1 were measured by immunohistochemistry integrated image analysis.RESULTS:The contents of BDNF in rat forehead cortex and hippocampus CA1 were obviously lower in the model group of 7 days and 21 days than those in the normal control group(P
