Transplantation of exogenous mesenchymal stem cells treats post-infarction ventricular remodeling in rats
- VernacularTitle:同种异体移植骨髓间质干细胞治疗大鼠心梗后心室重构
- Author:
Jie CHEN
;
Jianan WANG
;
Xinyang HU
;
Ronghua LUO
;
Xiaojie XIE
;
Jiahui LI
;
Aina HE
;
Yong SUN
- Publication Type:Journal Article
- Keywords:
Bone marrow mesenchymal stem cells;
Cell transplantation;
Ventricular remodeling;
Myocardial infarction
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:This study was performed to investigate the feasibility and efficiency of exogenous mesenchymal stem cells(MSCs) transplantation on post-infarction ventricular remodeling and heart function in rats and compare the effects between adult rat MSCs and neonate rat MSCs transplantation.METHODS:1-2 hours after left coronary artery ligation,MSCs cultured in ex vivo,marked with BrdU,were injected directly into the border of infarcts in exogenous rats.6 weeks after transplantation,rat' heart function,ventricular remodeling and pathological results were measured.RESULTS:MSCs transplantation decreased LV end-diastolic diameter and end-systolic diameter,limited LV chamber dilatation and reduced collagen content significantly.The numbers of blood vessels and cardiomyocytes were increased.BrdU-labelled MSCs with oval nucleus were widely distributed.There were no significant difference between adult rat MSCs and neonate rat MSCs transplanted groups.CONCLUSION:MSCs can survive and home in exogenous host infarct hearts without addition of any immunosuppressant.MSCs transplantation has benificial effects on remodeling processes and contributes to improvement of cardiac function,which may be related with the reduction of the amount of the collagen,promotion of myogenesis and angiogenesis.
