Determination of the Content of Menthol in Inclusion Complex of Compound Essential Oil-? -cyclodextrin by GC-MS
- VernacularTitle:GC-MS法测定复方精油-?-CD包合物中薄荷脑的含量
- Author:
Huaifu WANG
;
Rongsheng TONG
;
Maorong CHEN
;
Lin HE
- Publication Type:Journal Article
- Keywords:
GC-MS;
Essential oil;
?-cyclodextrin;
Inclusion complex;
Menthol;
Content determination
- From:
China Pharmacy
2005;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish GC-MS method for the determination of the Menthol in inclusion complex of compound essential oil-? -cyclodextrin. METHODS: Menthol was determined with ion fragment peak ( M/Z=71) . The chromatographic column was DM-5 fused silica capillary column ( 0. 25mm? 30m) ; the internal standard was naphthol and the temperature programming was 80～ 180℃ . RESULTS: The calibration curves of Menthol were linear in the ranges of 1. 344～ 10. 752? g? mL-1( r=0. 999 8) and the average recovery was 97. 52% , RSD=1. 56% . CONCLUSION: The method is rapid, accurate and reproducible, and suitable for the quality control of the same kind of the preparation.
