LOH and MSI of Fragile Histidine Triad Gene in laryngeal and hypopharyngeal carcinoma
- VernacularTitle:喉癌、喉咽癌脆性组氨酸三联体基因杂合性缺失和微卫星不稳定
- Author:
Qing JI
;
Qi WANG
;
Erzhong FAN
;
Han GAO
;
Hongbo XU
;
Ying LI
- Publication Type:Journal Article
- Keywords:
Chromosome Fragile Sites;
Microsatellite Repeats;
Loss of Heterozygosity;
Laryngeal Neo-plasms;
Hypopharyngeal Neoplasms
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).⑥ The incidence of MSI at D3S1234,D3S4103,D3S1300 in recurring cases was 83.33 %,but the ratio of MSI inprimary cases was 30.77 %,the former was remarkablyhigher than the latter(P=0.004).CONCLUSION ①Microsatellite analysis showed that both LOH andMSI of FHIT gene existed in laryngeal carcinoma andhypopharyngeal carcinoma,the former was morecommon.② FHIT gene participates the developmenof laryngeal carcinoma and hypopharyngeal carcinoma and may be one of the candidate tumor suppressor genes.③ MSI of FHIT gene may be correlated with recurrence of laryngeal and hypopharyngeal carcinoma.
