Decreased expression of Foxp3 in patients with allergic rhinitis
- VernacularTitle:叉头状转录因子3在变应性鼻炎中的表达
- Author:
Zhonglin MOU
;
Zhibin ZHAO
;
Huabin LI
;
Yenong TAN
;
Lei CHENG
- Publication Type:Journal Article
- Keywords:
Rhinitis,Allergic,Perennial;
Transcription Factors;
T-Lymphocytes
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the role of forkhead transcription factor p3(Foxp3) in the pathogenesis of allergic rhinitis(AR).METHODS Nasal tissues and peripheral blood mononuclear cells(PBMCs) were obtained from 17 patients with AR and 11 controls.Foxp3 was detected in nasal tissues by immunohistochemisry and real-time reverse transcription polymerase chain reaction(RT-PCR).Foxp3 and CD4+CD25+T cells were evaluated in PBMCs by using ? ow cytometry.RESULTS The numbers of Foxp3+ cells was(44.2?20.5)cells/mm2 and(129.5? 35.6)cells/mm2 in nasal mucosa of two groups(P
