The influence of anesthesia and means of postoperative pain control on T lymphocyte subtypes of blood in patients with rectal cancer
- VernacularTitle:麻醉与术后镇痛方法对老年直肠癌患者T细胞亚群的影响
- Author:
Yalan LI
;
Yunbo CHEN
;
Shihuang MO
;
Xuemei PENG
;
Xiaoping WANG
;
Changren ZHOU
- Publication Type:Journal Article
- Keywords:
Anesthesia, general;
Anesthesia, epidural;
Stress;
Hydrocortisone;
T-lymphocyte subsets
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the influence of anesthesia and different means of postoperative pain control on the T-lymphocyte during the perioperative period in patients with rectal cancer.METHODS: 40 adult patients, aged 65 or older, of American Society of Anesthesiologists (ASA) class 2-3 were divided into two groups according to the type and means of postoperative pain managements. Group Ⅰ (n=20) received intravenous anesthesia and patient controlled analgesia(PCA), fentanyl (13 ?g/kg) for post pain; group Ⅱ (n=20) received intravenous anesthesia plus lumber epidural anesthesia and epidural PCA of morphine 5 mg plus ropivacaine 100 mg for post operative pain. Blood samples from internal jugular vein were obtained before surgery, at the completion of surgery and 24, 48, and 120 h post surgery for detecting CD3+, CD4+, CD4/CD8 counts of peripheral T-lymphocytes. In addition, blood cortisol level and pain intensity were assessed by visual analogue score (VAS)at each time point. RESULTS: Baseline(before anesthesia) values of CD3+,CD4+, CD4/CD8 in patients were messured and there was a significant decrease of all these values from completion of surgery to 48 h after surgery in both groups (P
