Effect of Ginkgo biloba extract on the expression of connective tissue growth factor in the initiating stage of fibrosis in lungs of rats
- VernacularTitle:银杏叶提取物对大鼠肺纤维化初期肺结缔组织生长因子表达的影响
- Author:
Yanmin HUANG
;
Xiaoling CHEN
;
Ning XU
;
Wei LIU
;
Jie QI
;
Jianhui LIU
;
Jie AI
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba;
Connective tissue growth factor;
Pulmonary fibrosis;
Rats
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of Ginkgo biloba extract (GbE) on the expression of connective tissue growth factor (CTGF) in the initiating stage of pulmonary fibrosis of rats after administration of bleomycin (BLM).METHODS: The expression of CTGF in lungs was detected by Western blotting. The content of hydroxyproline was assayed by the method of chloramines T. The content of malondialdehyde (MDA) in plasma was investigated by colorimetry.RESULTS: On day 14 after administration of BLM, the contents of CTGF in lungs and MDA in plasma in BLM+NS group were higher than those in NS group, respectively (P
