Effect of dexamethasone on the adrenomedullin and its gene expression in lung tissue of asthmatic rats
- VernacularTitle:地塞米松对哮喘大鼠肺组织ADM及基因表达的影响
- Author:
Zhifeng ZHANG
;
Zhenxiang ZHANG
;
Huiguo LIU
- Publication Type:Journal Article
- Keywords:
Asthma;
Adrenomedullin;
Dexamethasone
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of dexamethasone (DEX) on the adrenomedullin (ADM) and its gene expression in lung tissue of asthmatic rats. METHODS: 30 healthy male SD rats were randomly divided into three groups (10 for each). The asthmatic model was established by ovalbumin inhalation and injection. The mRNA expression of ADM was examined by RT-PCR and the protein expression was detected by immunohistochemical method. The airway wall thickness, the airway smooth muscle (ASM) thickness and pulmonary tissue changes were observed under light microscope. RESULTS: The expression of ADM mRNA and protein in the asthma group A were higher than those in the control group(group C) (P
