Effect of Ganoderma lucidum spores on IL-1? and c-Fos in the brain tissue of epilepsy rats
- VernacularTitle:灵芝孢子粉对癫痫大鼠脑组织IL-1?与c-Fos的影响
- Author:
Weiqun WANG
;
Shuqiu WANG
;
Yuexia LIU
;
Xiaoru MA
;
Haibo YU
;
Baixin WANG
;
Dexin MENG
;
Mingliang ZHANG
- Publication Type:Journal Article
- Keywords:
Ganoderma lucidum spores;
Epilepsy;
Interleukin-1;
Protein, c-Fos
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the influence of Ganoderma lucidum spores on the cytokine IL-1? and c-Fos in the brain tissue of epilepsy rats. METHODS: The IL-1? level was examined by radioimmunoassay and the c-Fos expression was measured by immunohistochemical assay. RESULTS: Comparing the Ganoderma lucidum spores group with the epilepsy model group: c-Fos positive cell count in brain cortex and hippocampus in treatment group was obviously reduced. IL-1? level in brain tissue was also reduced obviously. CONCLUSION: Ganoderma lucidum spores effectively reduces cytokine IL-1? in brain tissue of epilepsy rats, improves the immunity dysfunction and plays a role in anti-epilepsy through suppressing c-Fos expression in epilepsy rats brain tissue and blocking of LRG.
