Effects of Shengmai San on oxidative damage in mentally stressed mice
- VernacularTitle:生脉散对应激小鼠组织氧化损伤的影响研究
- Author:
Muxin GONG
;
Lei WANG
;
Qian WANG
;
Yujuan LI
;
Tetsuya KONISHI
- Publication Type:Journal Article
- Keywords:
Shengmai San;
Oxidative injury;
Protein carbonyl;
Thiobarbituric acid reactive substances
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the preventive effects of Shengmai San (SMS) on oxidative damage in mentally stressed mice.METHODS: An oxidative stress mouse model was established by moustache-removed. Protein carbonyl and thiobarbituric acid reactive substance (TBARS) formation were determined as the oxidative stress markers.RESULTS: (1)Moustache-cut was founded to significantly enhance the behavioral movements of mice, especially large movements (movement 2 and rearing). SMS pre-administration inhibited the accelerated movements. (2) Protein carbonyl was increased in brain, heart, liver and kidney. TBARS in liver and heart increased in the moustache-cut mice, but SMS pretreatment inhibited the increased protein carbonyl and TBARS.CONCLUSION: SMS has the preventive effects on oxidative damage induced by emotional stress.
