Protective Effect of Hugan Granules on Acute Liver Injury Model Mice
- VernacularTitle:护肝颗粒对小鼠急性肝损伤的保护作用
- Author:
Zhong JIA
- Publication Type:Journal Article
- Keywords:
Hugan granules;
Acute liver injury;
Protective effect
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the protective effect of Hugan granules on the acute liver injury model mice. METHODS: Acute liver injury model was induced by intraperitoneal injection of 0.12% chloroform-peanut oil solution. The histopathological changes of the liver tissues were observed under microscope. The activities of ALT, AST and SOD and the content of MDA in the liver tissues were determined and the liver indexes were calculated. RESULTS: Hugan granules at high, medium and low doses could significantly lower serum ALT and AST activities, enhance the activity of SOD, and lower both MDA content and the liver index. CONCLUSION: Hugan granules have a certain protective effect on the acute liver injury.
