Effects of Ginkgolides Inhalation on Eosinophils Infiltration in Airway of Asthmatic Guinea Pig Model
- VernacularTitle:银杏内酯吸入剂对哮喘模型豚鼠气管嗜酸性粒细胞浸润的影响
- Author:
Jian GAO
;
Liang CHENG
;
Yi CHEN
;
Yu TANG
- Publication Type:Journal Article
- Keywords:
Ginkgolides;
Inhalation;
Bronchial asthma;
Eosinophils
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effects of Ginkgolides inhalation on eosinophils infiltration in airway of asthmatic guinea pig model. METHODS: Guinea pigs were divided into seven groups(n=8 in each group): model group, ginkgolides inhalation low, medium and high dosage groups(5, 10, 20mg?kg-1, respectively), ginkgolides ip group (at a dosage of 20 mg?kg-1), Dexamethasone ip group (at a dosage of 10 mg?kg-1), normal control group. The eosinophils (EOS) in bronchoalveolar lavage fluid (BALF) and trachea were counted. RESULTS: As compared with normal control group, the number of EOS in BALF was significantly increased in model group, but that in BALF and trachea of the Ginkgolides inhalation group was significantly reduced(P
