Preparation and Quality Control of Baicalin Dispersible Tablets
- VernacularTitle:黄芩苷分散片的制备及质量控制
- Author:
Qunliang SONG
;
Ping ZHANG
- Publication Type:Journal Article
- Keywords:
Baicalin;
Dispersible tablets;
Orthogonal experiment;
Content determination;
Dissolution rate
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare Baicalin dispersible tablets and establish a quality control method for this preparation. METHODS: The formula of Baicalin dispersible tablets was optimized by orthogonal experiment with disintegrating time as index. The content and dissolution rate of the tablets were determined by HPLC. RESULTS: The optimized formula was as follows: the contents of crospovidone, sodium starch glycolate and amylum pregelatinisatum were 40%, 6% and 2%, respectively. The dispersible tablets prepared in accordance with the optimize formula could disintegrate completely within 3 minutes and its dissolution rate could reach beyond 90% in 15 minutes. CONCLUSION: The preparation process is simple and feasible, and the prepared Baicalin dispersible tablets had a rapid disintegration and high dissolution rate.
