Expression of COX-2 and VEGF and their relation with cervical lymph metastases of papillary thyroid carcinoma
- VernacularTitle:环氧化酶-2和血管内皮生长因子与甲状腺癌颈淋巴转移的关系
- Author:
Hongyuan ZHU
;
Jianguo TANG
;
Xinli MAO
;
Guomin WU
;
Qin HUANG
- Publication Type:Journal Article
- Keywords:
Prostaglandin-Endoperoxide Synthase;
Thyroid Neoplasms;
Lymphatic Metastasis;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the relation of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expression with cervical lymph metastases in papillary thyroid carcinoma. METHODS The expression of COX-2 and VEGF in 79 specimens of papillary thyroid carcinoma were evaluated with SP immunohistochemical methods. In all the 79 cases, there were 46 cases with cervical lymph node metastases and 33 cases without cervical lymph node metastasis. RESULTS The positive expression rates of COX-2 and VEGF in the cases with cervical metastases were 81.6 % and 86.8 % respectively, and in the cases without cervical lymph metastases were 54.5 % and 66.7 % respectively. There was a significant difference in the positive expression rates of COX-2 and VEGF between two groups (P
