Effects of Felodipine on Blood Vessel Endothelial Function in Patients with Benign Prostatic Hyperplasia Complicating Essential Hypertension
- VernacularTitle:非洛地平对良性前列腺增生合并原发性高血压患者血管内皮功能的影响
- Author:
Yan LIU
;
Aiwu MA
;
Cunlong WANG
;
Zongcheng FENG
;
Yifei LIU
;
Ye WANG
- Publication Type:Journal Article
- Keywords:
Benign prostatic hyperplasia;
Essential hypertension;
Blood vessel endothelial function;
Felodipine
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of felodipine on blood vessel endothelial function in patients with benign prostatic hyperplasia(BPH) complicating essential hypertension(EH).METHODS:Fifty five patients with BPH complicating EH were assigned to receive 5mg felodipine orally qd for 6 weeks,with levels of endothelin-1(ET-1),nitrous oxide(NO) and von Wilebrand factor(vWF),brachial artery flow-mediated dilatation(FMD) function,the maximum urine flow rate,the average urine flow rate and International Prostate Symptom Score(I-PSS) determined before and after treatment.Meanwhile levels of ET-1,NO and vWF and FMD in 37 normal healthy males were determined.RESULTS:In the treatment group compared with normal control group there were significant differences in levels of ET-1,NO and vWF and FMD(P0.05).There were significant differences in ET-1,NO and vWF levels and FMD after treatment as compared with before treatment(P
