Effect of ? radioactive stent on proliferation and apoptosis of smooth muscle cells
- VernacularTitle:?粒子核素支架影响血管平滑肌细胞增殖与凋亡的实验研究
- Author:
Yingmei LIU
;
Yuewu FU
;
Li SUN
;
Yulin WEI
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Radioisotopes;
Stents;
Apoptosis;
Vascular Smooth muscle cells
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe effect of ? radioactive [103Pd] stent on the proliferation and apoptosis of smooth muscle cells, the mechanism of radioactive stent preventing in-stent restenosis was explored. METHODS: Fifty male New Zealand rabbits were randomized into stent group and [103Pd] stent group. Control group was set up. The materials were harvested on 3, 7, 14, 28, 56 days after operation and the following investigation were carried out, including pathomorphology, immunohistochemistry, apoptosis (TUNEL) and in situ hybridization studies.RESULTS: ① The severity of the stenosis in [103Pd] stent group was less severe than that in stent group. It was most obvious on 56 th day (P
