Selenium-enriched Spirulina platensis promotes proliferation of hepatocytes in rat partial hepatectomy
- VernacularTitle:富硒螺旋藻对肝叶切除大鼠肝细胞再生的促进作用
- Author:
Feng HUANG
;
Zhi HUANG
;
Wenjie ZHENG
;
Fang YANG
;
Zihai DING
- Publication Type:Journal Article
- Keywords:
Spirulina platensis;
Selenium;
Hepatectomy;
Proliferating cell nuclear antigen
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects of selenium-enriched Spirulina platensis (Se-SP) on proliferation of hepatocytes in rat hepatectomy. METHODS: Rat hepaectomy model was conducted using male Wistar rats. The rats were randomized into five groups: operation groups with 150 (H), 50 (M) and 15 (L) mg?kg-1?d-1 of Se-SP, placebo-control (P) and sham operation group (F). Activities of glutathione peroxidase (GPx) and thioredoxin reductases (TR) in hepatocytes were determined by chemical colorimetry. The expression index of proliferating cell nuclear antigen (PCNA) in hepatocytes was detected by immunohistochemistry, and the level of [3H]-TDR incorporation in regenerative hepatocytes was analyzed by radio-immunity. RESULTS: Activity of GPx and TR, PCNA expression index as well as [3H]-TDR insertion in hepatocytes (in vitro) were obviously higher (P
