Differences of AD-related parameters in SAM-P/8, SAM-R/1 and Kunming mice
- VernacularTitle:快速老化系小鼠与昆明系小鼠AD相关指标的比较
- Author:
Renbin QI
;
Daxiang LU
;
Huadong WANG
;
Zhen WANG
;
Jingjing HU
;
Yanping WANG
;
Yongmei FU
;
Chujie LI
- Publication Type:Journal Article
- Keywords:
SAM-P/8 mice;
SAM-R/1 mice;
Kunming mice;
Comparative study
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the differences of Alzheimer's disease(AD)-related parameters in the SAM-P/8, the SAM-R/1 and the Kunming mice.METHODS: The changes of ethology, neurobiochemistry (true choline esterase, TchE), ultrastructure and gene expression(gene chips) were determined in mice of three groups: SAM-P/8 mice (n=14), SAM-R/1 mice (n=14) and Kunming mice (n=14), which were 6 months old[weight(20?5)g].RESULTS: The SAM-P/8 mice had the inabilities of learning and memory compared with the SAM-R/1 mice and the Kunming mice (P
