A Correlativity Study About of the Expression of iNOS and AChE on Guinea Pigs Cochlea Damaged by Streptomycin
- VernacularTitle:链霉素耳中毒豚鼠耳蜗iNOS与AChE的表达及其相关性的实验研究
- Author:
Lijuan SHI
;
Hao TANG
- Publication Type:Journal Article
- Keywords:
Streptomycin;
Cochlea;
iNOS;
AChE
- From:
Journal of Audiology and Speech Pathology
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of iNOS and AChE during streptomycin ototoxicity and the correlation.Methods 16 guinea pigs were divided into 2 groups randomly:control group and SM group.SABC immunohistochemical staining and image quantitative analysis technique were used to observe the expression of iNOS and AChE and grey value analysis.ABR measurements were used to monitor the effects of ototoxity.Results After 10 days with drugs,the ABR threshold value of SM group increased more significantly than that of the control group(P
