The role of the expression of high mobility group box 1 in the pancreas of acute necrotizing pancreatitis in rats
- VernacularTitle:急性坏死性胰腺炎大鼠胰腺高迁移率族蛋白-1的表达及意义
- Author:
Feng ZHU
;
Jin LONG
;
Zhongye HE
;
Chunlin GE
;
Renxuan GUO
;
Kejian GUO
- Publication Type:Journal Article
- Keywords:
Pancreatitis,Acute Necrotizing/pathol;
High Mobility Group Box 1(HMGB1);
Models,Animal
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of change of high mobility group box 1(HMGB1)level of pancreas in acute necrotizing pancreatitis(ANP)in rats.Methods ANP model was induced by retrograde injection of sodium taurocholate in pancreatic duct.Animals were divided randomly into three groups:control group,ANP group,and sodium butyrate treatment group(treatment group).The serum levels of TNF-? and IL-1? were measured by ELISA.The HMGB1 mRNA level of pancreas was detected by RT-PCR.Results The serum levels of TNF-? and IL-1? were quickly increased after the model was induced,and reached a peak at 6h,but decreased at 12h.The HMGB1 mRNA level of pancreas was increased significantly at 12h,and maintained to 24h.Whereas in treatment group,the HMGB1 level of pancreas was lower than ANP group(P
