Optimization of the Formula of Retinoid Self-Emulsifying Preparation
- VernacularTitle:维甲酸自乳化制剂的处方筛选初步研究
- Author:
Linqing HUANG
;
Enjuan ZHANG
;
Qin GE
;
Tonghua LIU
;
Jian CAO
;
Zhen ZENG
- Publication Type:Journal Article
- Keywords:
Retinoid;
Self-emulsifying;
Drug delivery system;
Formula optimization
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To optimize the formula of retinoid self-emulsifying preparation. METHODS: The formula of retinoid self-emulsifying drug delivery system was optimized with the solubility of retinoid in different kinds/proportions of oil phases and surfactants as index through solubility test and drawing of ternary phase diagrams. RESULTS: The optimized formula ratio of retinoid self-emulsifying preparation was 0.01∶0.938∶0.402∶0.15 (retinoid / IPM/ Tween-85/ isopropanol, g∶g∶g∶mL). CONCLUSION: The retinoid self-emulsifying preparation prepared in accordance with the above-mentioned ratio is up to the related standard.
