Comparison of Dissolution Rate between Sanhuang Rapid-disintegrate Tablets and Sanhuang Sugar-coated Tablets
- VernacularTitle:三黄速崩片与糖衣片的溶出度比较
- Author:
Cuizhe LIU
;
Dawei CHEN
;
Kaishun BI
- Publication Type:Journal Article
- Keywords:
HPLC;
Sanhuang sugar coated tablets;
Sanhuang Rapid-disintegrate tablets;
Dissolution rate;
Baicalin
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To compare the dissolution rate between Sanhuang Rapid-disintegrate tablets and Sanhuang sugar-coated tablets. METHODS: The dissolution rates of two preparations of Sanhuang tablets were determined with baicalin as index in accordance with the dissolution determination method stated in China Pharmacopeia, with determination results subjected to statistical treatment. RESULTS: Significant differences were noted in the comparison of dissolution parameter between the two dosage forms. In aqueous medium, the cumulative dissolution rate of Sanhuang sugar-coated tablets at 45 min was 43%～73%, whereas that of the Rapid-disintegrate was above 90%. CONCLUSION: The dissolution rate of Sanhuang Rapid-disintegrate tablets is higher than that of Sanhuang sugar-coated tablets.
