Resistance Phenotype and Efflux Protein Gene Expression:Study of 51 Strains of Acinetobacter Baumannii
- VernacularTitle:51株鲍曼不动杆菌耐药表型及外排蛋白基因表达研究
- Author:
Tao DONG
;
Rui WANG
;
Weihang TONG
;
Dong CHAI
;
Fei PEI
;
Beibei LIANG
;
Yan FAN
;
Congran LI
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Multiple-drug resistance;
Active efflux;
Gene expression
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the resistance phenotype of acinetobacter baumannii and the expression of ade efflux pump gene. METHODS: Non-repetitive 51 strains of Acinetobacter baumannii were collected in Peking Union Medical Hospital between Feb. 2004 and Feb. 2005. The active efflux system adeB structural gene and sequence were identified by PCR. RESULTS: The tested strains were not susceptible to common broad-spectrum antibiotics. Multidrug resistant Acinetobacter baumannii carried adeB active efflux pump gene. CONCLUSION: The multiple-drug resistance of Acinetobacter baumannii is independent of ?-lactamase. It maybe related to other drug resistance mechanism. The effect of active efflux system is possibly one of the major mechanisms of multidrug resistance of acinetobacter baumannii.
