Effects of 5-hydroxymethylfurfural on Learning-memory and Brain Free Radical Metabolism in Cerebral Ischemia-Reperfusion Model Mice
- VernacularTitle:5-羟甲基糠醛对脑缺血再灌注模型小鼠学习记忆及脑部自由基的影响
- Author:
Ling ZHAO
;
Lan ZHANG
;
Yali LI
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
5-hydroxymethylfurfural;
Cerebral ischemia and reperfusion;
Learning-memory;
Free radical
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of 5-hydroxymethylfurfural on learning-memory and cerebral free radical metabolism in cerebral ischemia and reperfusion model mice. METHODS: The mice were divided into sham operation group, model group, 5-HMF low dose group, 5-HMF high dose group, and dihydroergotamine mesilate positive control group. After administration of the corresponding drugs, all groups except the sham operation group were subjected to construction of cerebral ischemia and reperfusion model. The learning-memory of mice was examined by Morris water maze and step-down tests, and cerebral superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were determined as well. RESULTS: In model group compared with sham operation group the escape latency and swimming distance were significantly prolonged in Morris water maze test (P
