Study on Anti-inflammatory and Analgesic Effects of Alkaloids of Corydalis Adunca Maxim
- VernacularTitle:灰绿黄堇生物总碱抗炎镇痛作用的研究
- Author:
Li ZHANG
;
Fang ZHANG
;
Jisheng WANG
;
Shangjiu HU
;
Taisheng LIU
- Publication Type:Journal Article
- Keywords:
Alkaloids of Corydalis adunca maxim;
Anti-inflammation;
Analgesia;
LD50;
95% creditability
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the pharmacological activities and toxicity of the crude alkaloids of Corydalis adunca maxim and to provide pharmacological data for further development of this herbal medicine. METHODS: The anti- inflammatory effects of the crude alkaloids of Corydalis adunca maxim were observed by using xylol and agra to induce the turgidness in the rats. The analgesic effects were observed by body distortion methods. The LD50 and 95% creditability were calculated with developed Karber Method. RESULTS: The administration of alkaloids of Corydalis adunca maxim had the function of inhibiting the auricle swelling caused by xylol and joint swelling caused by agar, and of decreasing the body- distortion of the rats. The LD50 of the crude alkaloids of Corydalis adunca maxim was 1. 833g. kg- 1 and the 95% creditability was 1. 18～ 2. 06g? kg- 1. CONCLUSIONS: The crude alkaloids of Corydalis adunca maxim has anti- inflammatory and analgesic effects in rats.
