Clinical Observations on Influences of Spleen-strengthening Decoction on the Expression of GLP-1 in Patients with Type Ⅱ Diabetes
- VernacularTitle:健胰方影响2型糖尿病患者肠促胰岛素GLP-1表达的临床观察
- Author:
Feng TAO
;
Zheng YAO
;
Hao LU
;
Yuandong SHEN
;
Gan CAI
- Publication Type:Journal Article
- Keywords:
Spleen-strengthening decoction;
Type Ⅱ diabetes;
GLP-1;
Glucagon;
Plasma glucose;
TCM symptom score
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effects of Spleen- strengthening decoction on GLP- 1 in patients with type II diabetes. METHODS: A randomized double- blind placebo- controlled test was conducted, and through observations for 8 wks, the changes of the two patient groups in plasma glucose, HbA1c, plasma GLP- 1 and Glucagon as well as TCM symptom score were measured for comparison. RESULTS: Before administration of Spleen- strengthening decoction, the two groups showed no significant difference in all of the indexes. After administration, the treatment group recorded lower indexes in fasting plasma glucose, HbA1c and plasma Glucagon, but higher index in fasting plasma GLP- 1, with no significant difference seen in other indexes. CONCLUSIONS: Spleen- strengthening decoction can improve glucose metabolism through heightening fasting plasma GLP- 1, and lowering both Glucagon and fasting plasma glucose.
