Stability Study on Gatifloxacin for Injection in Combination with Cimetidine Injection
- VernacularTitle:注射用加替沙星与西咪替丁注射液配伍稳定性考察
- Author:
Jizhang YANG
;
Ruiqin LIU
;
Shumin YANG
- Publication Type:Journal Article
- Keywords:
Gatifloxacin for injection;
Cimetidine injection;
Compatibility;
Stability;
UV spectrophotometry
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the compatible stability of gatifloxacin for injection and cimetidine injection in 0.9% sodium chloride injection or in 5% glucose injection.METHODS:Changes in appearance and pH value of gatifloxacin in combination with cimetidine within 8 hours after mixing were respectively observed and determined under room temperature(20?1)℃,and the content was determined by UV spectrophotometry.RESULTS:No significant change was seen in appearance and pH value after two hours of mixing of the two agents.But after four hours of mixing,the content of cimetidine went up in both solvents,and its pH value rose slightly in 0.9% sodium chloride injection.CONCLUSION:Gatifloxacin for injection can be mixed with cimetidine injection in 0.9% sodium chloride injection or 5%glucose for injection to use,but the compatible liquid should be used up in 2 hours.
