A Case Control-study on the Associations between Polymorphism of GSTT1,GSTM1 and Susceptibility for Breast Cancer
- VernacularTitle:GSTT1基因、GSTM1基因多态性与乳腺癌易感性的病例-对照研究
- Author:
Jun MA
;
Zhuang CUI
;
Zhong SUN
- Publication Type:Journal Article
- Keywords:
Breast cancer;
GSTT1;
GSTM1;
Polymorphism;
Case-control study
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation of the polymorphism of GSTT & GSTM1 genes with the susceptibility of breast cancer.Methods A hospital-based case-control study was conducted,and 105 normal women as a control group and 100 women cases with breast cancer were recruited.The polymorphism of GSTT1 and GSTM1 were assessed by polymerase chain reaction(PCR).Logistic regression was conducted to evaluate the odds ratio of breast cancer in relation to single,multiple gene and estrogen exposure factors.Results The results showed that significant difference was found in the distribution of GSTT1,GSTM1 between controls and cases.There was a negative correlation between CSTT1 & GSTM1 and the risk of breast cancer with OR of 2.133 and 2.458,respectively.Polygenic model analysis indicated that there was a statistically significant correlation of the vacancy of GSTT1 & GSTM1 with breast cancer.Furthermore,it was also revealed that individual in simultaneous lack of GSTT1 and GSTM1 would run 12 times as high risk as normal controls did(OR=12.338).Results from unconditional logistic regression analysis showed that GSTT1 and GSTM1 were significantly associated with the occurrence of breast cancer.Conclusion The study indicated that the polymorphisms of estrogen-metabolizing genes were related to the risk of breast cancer.
