Optimizing the Extraction of Alkaloids from Rhizoma Coptidis by Orthogonal Design
- VernacularTitle:正交试验优化提取黄连中小檗碱型生物碱
- Author:
Yi YING
;
Zhihong HE
;
Shiwen ZHOU
;
Jianlin TANG
;
Yongping HUANG
;
Xue YANG
- Publication Type:Journal Article
- Keywords:
Rhizoma Coptidis;
Alkaloids;
Orthogonal test
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the optimized process for extraction of the alkaloids from Rhizoma Coptidis.METHODS:Orthogonal design was used for studying the effect of alcohol concentration,volume,extraction time and times on the content of jatrorrhizine,epiberberine,coptisine,palmatine and berberine.RESULTS:The optimum extraction process is as follows:8 times of 50% alcohol,extracted for 4 times,each time for 2 hours.CONCLUSION:This extraction process is workable and reproducible,and can provide theoretic support for mass extraction of the alkaloids from Rhizoma Coptidis.
