Determination of the Content of Morphine in Pipazhike Soft Capsules by SEP-HPLC
- VernacularTitle:固相萃取-高效液相色谱法测定枇杷止咳胶囊中吗啡的含量
- Author:
Hong QIU
;
Baojia WANG
;
Fang LIN
- Publication Type:Journal Article
- Keywords:
SPE-HPLC;
Pipazhike soft capsules;
Morphine;
Content determination
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for determination of Morphine in Pipazhike soft capsules by using SPE-HPLC.METHODS:SPE condition:C18 cartridge.15mL MeOH-water(3∶ 1)and 5mL water were used as elution solvent.RESULTS:Morphine had a good linearity in the rang of 0.233 5～ 1.868 0? g(r=0.999 9).The average recovery rate was 97.6%(RSD=1.2%,n=5).CONCLUSION:This method is simple,accurate,and reproducible,and can be used to effectively control the content of Morphine in Pipazhike soft capsules.
