The trend of primary antibiotics resistance of Helicobacter pylori (HP) to metronidazole, clarithromycin and amoxicillin over 10 years (1993-2002)
- Author:
Bang Van Nguyen
- Publication Type:Journal Article
- Keywords:
helicobacter pylori;
primary antibiotics resistance;
adult;
children
- MeSH:
Helicobacter pylori;
Drug Resistance;
Microbial;
- From:Journal of Preventive Medicine
2007;1(17):39-44
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: the selection of appropriate antibiotics decided success in healing stomach-duodenum lesions. Regimens were recommended over the world today in treatment of stomach-duodenal ulcers were combination ofthree drugs, including an anti-gastric acid secretion agent and two of three antibiotics were amoxicillin (Amox), clarithromycin (Clar) and metronidazole (Metro). In Vietnam, a recent study showed that 76% of HP strains resistant to Metro and 1% resistant to Clar. Objectives: to describe prevalence and trend of primary antibiotics resistance of H.pylori to metronidazole, clarithromycin and amoxicillin over 10 years (1993-2002). Subjectives and Method: A retrospective study was about the susceptibility of 434 HP isolates derived from 281 children and 153 adults to Metro, Clar and Amox for 10 years (1993-2002) by using E-test. Results: no isolates resistant to Amox had been identified. Overall resistance rates of HP isolates to Metro, Clar and to both of them were 48.9%, 31.5% and 17.1% (51.7%, 28.4% and 17.6% in children and 43.7%, 36.6% and 16.3% in adults). Metro resistance rate in children aged from 10 to 18 was higher than that in adults and younger children (p<0.04). Clar resistance rate of children under 10 was lower than that of older children and adults (p<0.02). Both MICs of dual resistant isolates to Metro and Clar were higher than that of single resistant isolates (p<0.02 with Metro and p<0.01 with Clar). Conclusions: resistance rates of HP isolates to Metro, Clar and to both of them were relatively high. No isolates resistant to Amox had been identified. Antibiotics resistance rates in children were difference between the ages.
