Effects of Jieminqufeng decoction on the histomorphological changes of nasal mucosa in rats with allergic rhinitis
- VernacularTitle:截敏祛风汤治疗大鼠变应性鼻炎鼻黏膜的变化
- Author:
Xuhui KONG
;
Yongjiu HUANG
;
Zhaoxin MA
;
Ping HUANG
;
Ming LI
;
Ling QI
;
Xueli BAO
- Publication Type:Journal Article
- Keywords:
Rhinitis,Allergic,Perennial;
jieminqufeng decoction;
Histology
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the curative effect of Jieminqufeng decoction to the rats with allergic rhinitis. METHODS Fourty Wistar rats were randomly divided into 4 groups. There were Jieminqufeng decoction group (A),cetirizine group (B),model control group(C) and normal control group (D). The rats with allergic rhinitis were established with ovalbumin. The behavioral changes of the rats were observed. The histological and cellular morphological changes were studied with light microscope and transmission electron microscope. RESULTS The model control (C) group had typical symptoms of allergic rhinitis. By light microscope and transmission electron microscope,a lot of eosinophilic granulocytes were found in nasal mucosa. The mucosal cells were lost or destroyed. However,the histological and cellular morphological changes of nasal mucosa in Group A,B were similar to that in Group D. CONCLUSION The Jieminqufeng decoction is an effective drug to treatment of allergic rhinitis. It can decrease the aggregation and activation of eosinophilic granulocytes,lessen inflammatory reaction and block up the allergy.
