Effects of Xuebijing injection(血必净注射液) on tissue tumor necrosis factor-? and blood coagulation parameters in septic rats
- VernacularTitle:血必净注射液对脓毒症大鼠组织肿瘤坏死因子-?及凝血功能的影响
- Author:
Yingping LI
;
Youjie QIAO
;
Zixia WU
;
Yongming YAO
;
Yan YU
;
Yao WU
- Publication Type:Journal Article
- Keywords:
sepsis;
Xuebijing injection;
tumor necrosis factor-?;
blood coagulation
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of traditional Chinese medicine Xuebijing injection (血必净注射液) on tissue tumor necrosis factor-?(TNF-?) expression and blood coagulation parameters in septic rats.Methods: Wistar rats were subjected to sepsis induced by cecal ligation and puncture(CLP).Ninety-six healthy rats were randomly divided into four groups: normal group,sham operation group,CLP model group,and Xuebijing-treated group.The two latter groups were given respectively intravenous injection of normal saline or Xuebijing injection with the dose of 4 ml/kg at 0.5,12,24,36,48 and 60 hours after the establishment of CLP model.Eight rats were sacrificed at 2,8,24,48 and 72 hours postCLP in the two latter groups.Prothrombin time(PT),activated partial thromboplastin time (APTT),and fibrinogen(Fbg) levels were determined.Tissue TNF-? protein levels in liver and lung tissues were also measured at various intervals.Results: TNF-? protein levels in liver and lung tissues were significantly increased at 2 hours after establishment of CLP model compared with those of the normal group(both P
