Effect of Feibi Decoction on p38 MAPK and Transforming Growth Factor ?_1 of Pulmonary Tissue in Rats with Pulmonary Fibrosis
- VernacularTitle:肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子?_1的影响
- Author:
Yang JIAO
;
Tianyu GUAN
;
Pingan ZHOU
- Publication Type:Journal Article
- Keywords:
Pulmonary fibrosis;
p38 MAPK;
TGF-?1;
Feibi Decoction
- From:
Journal of Traditional Chinese Medicine
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and mechanism of Feibi Decoction on pulmonary fibrosis.Methods SD rats were randomly divided into sham-operation group,model control group,Feibi Decoction large-close group,Feibi Decoction mid-dose group,Feibi Decoction samll-dose group and western medicine control group,each of 10 rats.Bleomycetin was used to copy rat's pulmonary fibrosis model.Feibi decoction was drenched to rats in large,medium and small dose of Chinese medicine groups.Prednisone was given to werstern medicine control group.The rats were executed 28 days later.The expression of p38 MAPK and transforming growth factor ?1(TGF-?1) was tested.Results In comparison with sham operation,Chinese medicine and western medicine groups,the expression of p38 MAPK and TGF-?1 in model control group increased significantly(P
