Changes of L-arginine,NOS/NO pathway in adventitia of rats with sepsis
- VernacularTitle:败血症休克大鼠血管外膜L-精氨酸/一氧化氮合酶/一氧化氮通路的变化
- Author:
Yuexia JIA
;
Chongshui PAN
;
Jinghui YANG
;
Bin GENG
;
Jing ZHANG
;
Jing ZHAO
;
Chaoshu TANG
;
Yongfen QI
- Publication Type:Journal Article
- Keywords:
Shock, septic;
Arginine;
Nitric-oxide synthase;
Nitric oxide
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: In this study, we aimed to explore the alteration and pathophysiological significance of the L-arginine (L-Arg)/NOS/NO pathway in the adventitia of rats with sepsis. METHODS: Sepsis was induced by cecal ligation and puncture (CLP). Rat cardiac function was determined. NO generation, NOS activity and L-Arg transport were measured. The iNOS mRNA levels was determined by using RT-PCR. RESULTS: Cecal ligation and puncture induced severe sepsis with severe low glucose, high lacticemia and cardiac function inhibition. The iNOS activity was increased by 2.8-fold compared with controls (P
