Expression of GLUT4 in endometrium of rats with polycystic ovary syndrome
- VernacularTitle:GLUT4在多囊卵巢综合征大鼠子宫内膜中的表达及意义
- Author:
Wei WANG
;
Jianhui CAI
;
Yumei MA
;
Suxin XU
;
Guimin HAO
;
Xiaodong LI
- Publication Type:Journal Article
- Keywords:
Glucose transporter-4;
Polycystic ovary syndrome;
Endometrium;
Insulin resistance;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the expression of glucose transporter 4 (GLUT4) in the endometrium of rats with polycystic ovarian syndrom (PCOS) and evaluate the relationship between GLUT4 expression and insulin resistance (IR). METHODS: 54 female SD rats of 85 days were randomized to control group (n=20), PCOS model group (n=17) and metformin treatment group (n=17). The rats in the latter two groups were induced by Poretsky's method for PCOS model, followed by placebo or metformin, respectively. After 14 days of treatment, the rats were sacrificed and the expression of GLUT4 in endometrium was detected by ElivisionTM Plus two steps immunohistochemical staining. RESULTS: The expression of GLUT4 and insulin receptor(INS-R) proteins of endometrial glandulan epitheliu in PCOS rats were significantly lower (P
