Protective effect of ischemic preconditioning on liver ischemic-reperfusion injury of liver transplant in rats
- VernacularTitle:供肝缺血预处理对大鼠肝移植缺血再灌注损伤的保护性作用
- Author:
Xincai QU
;
Jiliang WANG
;
Tao QIN
;
Qichang ZHENG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Ischemic preconditioning;
Ischemic-reperfusion;
Nitric oxide;
TNF-?;
Muridae
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect and mechanism of warm ischemic preconditioning of on liver cold ischemic-reperfusion injury of donor liver in rats. Methods Male Sprague Dawley rats were used as donors and recipients of orthotopic liver transplantation, the cold ischemia period and anhepatic phase was 120 min and 16～20 min respectively. Rats were randomly divided into 3 groups: sham-operation group, liver transplantation group, and ischemic pre-conditioning(IP) group. IP was performed with 5-min ischemia followed by 5-min reperfusion. Results After operation, the serum levels of ALT and superoxide were significantly higher in the groups of liver transplantation and IP group than in the sham-operation group(P
