Study on the PKC in signal transduction pathway in hepatocyte ischemic preconditioning
- VernacularTitle:肝脏缺血预处理所致PKC活性改变及细胞内信号转导机制的实验研究
- Author:
Mingxin PAN
;
Yi ZHANG
;
Aihui LI
;
Yi GAO
- Publication Type:Journal Article
- Keywords:
Liver Ischemia;
Ischemic Preconditioning;
Protain Kinase C;
Signal transduction;
Muridae
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of alternation of PKC activify in liver ischemia preconditioning(IP). Methods After establishment of rat liver IP model, PKC inhibitor and activator were utilized to analyze the phosphorylation of PKC and P44/42MAPKs and HSP expression, and cellular structure was also observed. All of the data were statistically analyzed. Results Compared with the control group without IP, the phosphorylation of PKC was significantly increased in IP treated models and PKC activated group(P
