In Vitro Study on the Transdermal Permeation Enhancing Effect of N-trimethyl Chitosan on Estradiol Gels
- VernacularTitle:N-三甲基壳聚糖对雌二醇凝胶透皮促进作用的体外研究
- Author:
Wen HE
- Publication Type:Journal Article
- Keywords:
N-trimethyl chitosan;
Estradiol;
Gels;
Transdermal permeation enhancing;
In vitro
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the enhancing effect of N-trimethyl chitosan with degree of quaternization of 60% (TMC60) on the estradiol gel in vitro. METHODS: TMC60 was synthesized and the degree of quaternization was determined by 1H-NMR. Three different kinds of estradiol gels, 2% TMC60 group, 2% azone group and blank control group, were studied respectively. The cumulative penetration Q and steady penetration rate J in vitro were used as the indices. The cumulative penetration was calculated. RESULTS: The degree of quaternization of TMC60 was 67.2%. Significant difference was found the value Q and J of TMC60 group when compared to blank control group(P0.05). CONCLUSION: 2% TMC60 is a penetration enhancer with similar enhancing effect as 2% Azone, which deserves further research.
