Preparation and Determination of Indomethacin-hydroxypropy-cyclodextrin Inclusion Complex Ointments
- VernacularTitle:吲哚美辛-羟丙基-?-环糊精包合物软膏的制备及含量测定
- Author:
Lan YU
;
Fangfang QIN
- Publication Type:Journal Article
- Keywords:
Indomethacin;
Hydroxypropy-cyclodextrin inclusion complex;
Ointments;
Preparation;
Content determination
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare Indomethacin-hydroxypropy-cyclodextrin inclusion complex ointments and establish its assay method. METHODS: The preparation was prepared with O/W type emulsion ointment as base material, and the content of Indomethacin in which was determined by UV spectrophotometry. RESULTS: The calibration curve of Indomethacin was linear in the range of 16.76～41.91?g?mL-1(r=0.999 6),and its average recovery was 99.53%(RSD=1.50%). CONCLUSION: The ointments were convenient in preparation technique, and simple and accurate in determination.
